A mutational signature that can be made by a bacterium arises in human colon cancer | Nature
Studies have pointed to a link between colon cancer and a gut bacterium that produces DNA-damaging molecules. The discovery of a mutational signature linked to these bacteria in human colon cancer supports this association.
HiChIP-Peaks: A HiChIP peak calling algorithm | Bioinformatics
HiChIP is a powerful tool to interrogate 3D chromatin organization. Researchers develop a new tool based on a representation of HiChIP data centred on the re-ligation sites to identify peaks from HiChIP datasets, which can subsequently be used in other tools for loop discovery.
Genomic characterization of human brain metastases identifies drivers of metastatic lung adenocarcinoma | Nature Genetics
Brain metastases from lung adenocarcinoma (BM-LUAD) frequently cause patient mortality. To identify genomic alterations that promote brain metastases, researchers performed whole-exome sequencing of 73 BM-LUAD cases. Using case-control analyses, they discovered candidate drivers of brain metastasis by identifying genes with more frequent copy-number aberrations in BM-LUAD compared to 503 primary LUADs. These results demonstrate that somatic alterations contribute to brain metastases and that genomic sequencing of a sufficient number of metastatic tumors can reveal previously unknown metastatic drivers.