Bench pressing with genomics benchmarkers | Nature Methods
Some -omics tools can be more accurate, sensitive or efficient than others. Yet benchmarking is no tell-all.
Pathway paradigms revealed from the genetics of inflammatory bowel disease | Nature
Inflammatory bowel disease (IBD) is a complex genetic disease that is instigated and amplified by the confluence of multiple genetic and environmental variables that perturb the immune–microbiome axis. Here the authors describe IBD as a model disease in the context of leveraging human genetics to dissect interactions in cellular and molecular pathways that regulate homeostasis of the mucosal immune system.
A neural network unpicks the knots | Nature
Machine learning can tell different types of knot apart just by ‘looking’ at them. For decades, mathematicians have had algorithms that calculate whether any two knots are of the same type — that is, whether the knots can be converted into each other without cutting the string. Researchers created geometric models of the five simplest knots and fed those models into neural networks, which are computing systems modelled after the brain’s networks of neurons. After training on hundreds of thousands of such models, the networks had learnt to classify knots with 99% accuracy or better.