Extrachromosomal DNA amplifications in cancer | Nature Reviews Genetics
Extrachromosomal DNA (ecDNA) amplification is an important driver alteration in cancer. It has been observed in most cancer types and is associated with worse patient outcome. In this Review, the authors synthesize what is currently known about how ecDNA is generated and how its genetic and epigenetic architecture affects proto-oncogene deregulation in cancer.
De novo spatiotemporal modelling of cell-type signatures in the developmental human heart using graph convolutional neural networks | PLOS Computational Biology
With the emergence of high throughput single cell techniques, the understanding of the molecular and cellular diversity of mammalian organs have rapidly increased. Here reseachers applied a de novo technique to spatially resolve and characterize cellular diversity of in situ sequencing data during human heart development.
Detection of orthologous exons and isoforms using EGIO | Bioinformatics
Alternative splicing is an important mechanism to generate transcriptomic and phenotypic diversity. Researchers develop a new method, EGIO, to detect orthologous exons and orthologous isoforms from two species.