Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2 | Science
Scientists are racing to learn the secrets of severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2), which is the cause of the pandemic disease COVID-19. The first step in viral entry is the binding of the viral trimeric spike protein to the human receptor angiotensin-converting enzyme 2 (ACE2). Yan et al. present the structure of human ACE2 in complex with a membrane protein that it chaperones, B0AT1. In the context of this complex, ACE2 is a dimer. A further structure shows how the receptor binding domain of SARS-CoV-2 interacts with ACE2 and suggests that it is possible that two trimeric spike proteins bind to an ACE2 dimer. The structures provide a basis for the development of therapeutics targeting this crucial interaction.
How cancer genomics is transforming diagnosis and treatment | Nature Outlook
Genome sequencing is providing physicians with more data about the causes of cancer and changing the way some forms of the disease are treated.
Seven quick tips for analysis scripts in neuroimaging | PLOS Computational Biology
In neuroimaging, as in many fields, the journey of the data from the measurement equipment to a figure in a publication is growing longer and more complicated. This article is a guide for those who have already written their own data analysis pipelines and wish to improve their designs.