The International Cancer Genome Consortium Data Portal | Nature Biotechnology
The International Cancer Genome Consortium (ICGC) dataset is available at https://dcc.icgc.org/. Data access is governed by the ICGC Data Access Office for non-US projects and by the dbGaP Authorized Access program for US-based projects. Software code of the ICGC infrastructure, including the ICGC Data Portal, is available at https://github.com/icgc-dcc under the GNU General Public License Version 3.
The genomic landscape of pediatric cancers: Implications for diagnosis and treatment | Science
Whereas many adult cancers are characterized by a high number of somatic mutations, pediatric cancers typically have few somatic mutations but a higher prevalence of germline alterations in cancer predisposition genes. Researchers discuss evidence that points to a need for more integrative approaches aimed at identifying driver events in pediatric cancers at both diagnosis and relapse. They also provide an overview of key aspects of germline predisposition for cancer in this age group.
A complete statistical model for calibration of RNA-seq counts using external spike-ins and maximum likelihood theory | PLOS Computational Biology
Researchers present a complete statistical model for the analysis of RNA-seq data from a population of cells using external RNA spike-ins and a maximum-likelihood method for genome-wide estimation of transcripts per cell. The model includes biological variability of cellular transcript number and sampling noise.